Assay Detail
Binding
CHEMBL762238
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Binding affinity against human oxytocin receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.66 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1429 | DESMOPRESSIN | 4.0 | 1 | 8.30 |
| CHEMBL2369839 | — | — | 1 | 7.59 |
| CHEMBL411148 | — | — | 1 | 7.31 |
| CHEMBL2369831 | — | — | 1 | 7.04 |
| CHEMBL1790575 | — | — | 1 | 6.99 |
| CHEMBL2369842 | — | — | 1 | 6.90 |
| CHEMBL221436 | — | — | 1 | 6.87 |
| CHEMBL2369830 | — | — | 1 | 6.84 |
| CHEMBL2369847 | — | — | 1 | 6.79 |
| CHEMBL2369838 | — | — | 1 | 6.69 |
| CHEMBL268306 | — | — | 1 | 6.68 |
| CHEMBL2369829 | — | — | 1 | 6.65 |
| CHEMBL2369840 | — | — | 1 | 6.65 |
| CHEMBL265858 | — | — | 1 | 6.62 |
| CHEMBL375096 | — | — | 1 | 6.49 |
| CHEMBL2369848 | — | — | 1 | 6.43 |
| CHEMBL2369834 | — | — | 1 | 6.32 |
| CHEMBL80877 | — | — | 1 | 6.25 |
| CHEMBL2369835 | — | — | 1 | 6.18 |
| CHEMBL2369841 | — | — | 1 | 5.99 |
| CHEMBL375324 | — | — | 1 | 5.96 |
| CHEMBL2369836 | — | — | 1 | 5.87 |
| CHEMBL2369837 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1429 | DESMOPRESSIN | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2369839 | — | Ki | = | 25.6 | nM | 7.59 |
| CHEMBL411148 | — | Ki | = | 48.7 | nM | 7.31 |
| CHEMBL2369831 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL1790575 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL2369842 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL221436 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL2369830 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL2369847 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL2369838 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL268306 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL2369829 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL2369840 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL265858 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL375096 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL2369848 | — | Ki | = | 369.0 | nM | 6.43 |
| CHEMBL2369834 | — | Ki | = | 482.0 | nM | 6.32 |
| CHEMBL80877 | — | Ki | = | 556.0 | nM | 6.25 |
| CHEMBL2369835 | — | Ki | = | 664.0 | nM | 6.18 |
| CHEMBL2369841 | — | Ki | = | 1033.0 | nM | 5.99 |
| CHEMBL375324 | — | Ki | = | 1083.0 | nM | 5.96 |
| CHEMBL2369836 | — | Ki | = | 1364.0 | nM | 5.87 |
| CHEMBL2369837 | — | Ki | = | 1429.0 | nM | 5.84 |