Assay Detail
Binding
CHEMBL1253116
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Displacement of [3H]-oxytocin from human oxytocin receptor expressed in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oral oxytocin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.83 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1253499 | — | — | 1 | 9.30 |
| CHEMBL31065 | — | — | 1 | 8.70 |
| CHEMBL1254024 | — | — | 1 | 7.55 |
| CHEMBL1254025 | NOLASIBAN | 3.0 | 1 | 7.02 |
| CHEMBL1253935 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1253499 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL31065 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1254024 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1254025 | NOLASIBAN | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL1253935 | — | Ki | = | 260.0 | nM | 6.58 |