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Assay Detail

CHEMBL1253141

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-oxytocin from human oxytocin receptor expressed in HEK293-EBNA cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293-EBNA
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Oxytocin receptor (CHEMBL2049)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Oral oxytocin antagonists.
Borthwick AD.
J Med Chem (2010) 53 : 6525 -6538
PubMed 20550119 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 9 7.66 9.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL445816 1 9.19
CHEMBL467378 1 8.22
CHEMBL594828 1 8.02
CHEMBL1254117 1 7.85
CHEMBL492029 1 7.55
CHEMBL1254210 1 7.30
CHEMBL1254297 1 7.25
CHEMBL1254116 1 7.05
CHEMBL467154 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL445816 Ki = 0.65 nM 9.19
CHEMBL467378 Ki = 6.0 nM 8.22
CHEMBL594828 Ki = 9.5 nM 8.02
CHEMBL1254117 Ki = 14.0 nM 7.85
CHEMBL492029 Ki = 28.0 nM 7.55
CHEMBL1254210 Ki = 50.0 nM 7.30
CHEMBL1254297 Ki = 56.0 nM 7.25
CHEMBL1254116 Ki = 90.0 nM 7.05
CHEMBL467154 Ki = 304.0 nM 6.52