Assay Detail
Functional
CHEMBL1259255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
74
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 74 | 7.38 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1259155 | — | — | 1 | 8.18 |
| CHEMBL1259124 | — | — | 1 | 8.07 |
| CHEMBL1259241 | — | — | 1 | 8.00 |
| CHEMBL1259209 | — | — | 1 | 7.96 |
| CHEMBL1259033 | — | — | 1 | 7.92 |
| CHEMBL1259151 | — | — | 1 | 7.89 |
| CHEMBL1259034 | — | — | 1 | 7.82 |
| CHEMBL1258999 | — | — | 1 | 7.80 |
| CHEMBL1259071 | — | — | 1 | 7.77 |
| CHEMBL1259200 | — | — | 1 | 7.75 |
| CHEMBL1259032 | — | — | 1 | 7.75 |
| CHEMBL1259087 | — | — | 1 | 7.70 |
| CHEMBL1259107 | — | — | 1 | 7.70 |
| CHEMBL1259210 | — | — | 1 | 7.58 |
| CHEMBL1259072 | — | — | 1 | 7.52 |
| CHEMBL1259139 | — | — | 1 | 7.52 |
| CHEMBL1259184 | — | — | 1 | 7.50 |
| CHEMBL1259016 | — | — | 1 | 7.47 |
| CHEMBL1259122 | — | — | 1 | 7.46 |
| CHEMBL1259036 | — | — | 1 | 7.44 |
| CHEMBL1259109 | — | — | 1 | 7.41 |
| CHEMBL1259121 | — | — | 1 | 7.38 |
| CHEMBL1259138 | — | — | 1 | 7.34 |
| CHEMBL1259223 | — | — | 1 | 7.33 |
| CHEMBL1259224 | — | — | 1 | 7.32 |
| CHEMBL1259198 | — | — | 1 | 7.30 |
| CHEMBL1259181 | — | — | 1 | 7.28 |
| CHEMBL1259153 | — | — | 1 | 7.27 |
| CHEMBL1259123 | — | — | 1 | 7.23 |
| CHEMBL1255610 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1259155 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1259124 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL1259241 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1259209 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1259033 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1259151 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1259034 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1258999 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1259071 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1259200 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1259032 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1259107 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1259087 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1259210 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1259139 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1259072 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1259184 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1259016 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1259122 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1259036 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1259109 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1259121 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1259138 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1259223 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1259224 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1259198 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1259181 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1259153 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1259123 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1255610 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1259090 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1259089 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1259035 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1259165 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL1259055 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1259108 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1259051 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1259242 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3084757 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1259017 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1258996 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1259073 | — | EC50 | - | — | - | |
| CHEMBL1259182 | — | EC50 | - | — | - | |
| CHEMBL3084758 | — | EC50 | - | — | - | |
| CHEMBL3084758 | — | EC50 | - | — | - | |
| CHEMBL1259168 | — | EC50 | - | — | - | |
| CHEMBL1259054 | — | EC50 | - | — | - | |
| CHEMBL1259074 | — | EC50 | - | — | - | |
| CHEMBL1259167 | — | EC50 | - | — | - | |
| CHEMBL1259150 | — | EC50 | - | — | - |