Assay Detail
Binding
CHEMBL1259259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Ketanserin from 5-HT2 receptor in pig cortex membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.58 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1259071 | — | — | 1 | 4.75 |
| CHEMBL1259241 | — | — | 1 | 4.66 |
| CHEMBL45305 | BEFIRADOL | 2.0 | 1 | 4.64 |
| CHEMBL1258999 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1259071 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1259241 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL45305 | BEFIRADOL | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL1258999 | — | Ki | = | 53000.0 | nM | 4.28 |