Assay Detail
Functional
CHEMBL1259377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as time point of maximal current amplitude by patch-clamp electrophysiology
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL6007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Analogues of morphanthridine and the tear gas dibenz[b,f][1,4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.67 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1085102 | — | — | 1 | 8.36 |
| CHEMBL1084637 | — | — | 1 | 8.13 |
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | 1.0 | 1 | 5.24 |
| CHEMBL55285 | BENZYL ISOTHIOCYANATE | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1085102 | — | EC50 | = | 4.365 | nM | 8.36 |
| CHEMBL1084637 | — | EC50 | = | 7.413 | nM | 8.13 |
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | EC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL55285 | BENZYL ISOTHIOCYANATE | EC50 | = | 10964.78 | nM | 4.96 |