Assay Detail
Functional
CHEMBL1259558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against acyclovir-resistant HSV1 KOS infected in HEL assessed as reduction in virus-induce cytopathicity
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.63 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1255998 | — | — | 1 | 9.07 |
| CHEMBL1258440 | — | — | 1 | 8.64 |
| CHEMBL1258896 | — | — | 1 | 8.57 |
| CHEMBL1258777 | — | — | 1 | 8.15 |
| CHEMBL1258328 | — | — | 1 | 8.15 |
| CHEMBL1258661 | — | — | 1 | 7.77 |
| CHEMBL1258212 | — | — | 1 | 7.77 |
| CHEMBL1258549 | — | — | 1 | 7.28 |
| CHEMBL261240 | — | — | 1 | 5.87 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.86 |
| CHEMBL1257161 | — | — | 1 | 5.62 |
| CHEMBL1258897 | — | — | 1 | 5.53 |
| CHEMBL1257279 | — | — | 1 | 5.51 |
| CHEMBL1257162 | — | — | 1 | 5.48 |
| CHEMBL1257399 | — | — | 1 | 5.45 |
| CHEMBL1255999 | — | — | 1 | 5.44 |
| CHEMBL1258211 | — | — | 1 | 5.32 |
| CHEMBL1257278 | — | — | 1 | 5.30 |
| CHEMBL1257400 | — | — | 1 | 5.15 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1255998 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL1258440 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1258896 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1258777 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1258328 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1258661 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1258212 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1258549 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL261240 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL1257161 | — | EC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL1258897 | — | EC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL1257279 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1257162 | — | EC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL1257399 | — | EC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL1255999 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1258211 | — | EC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL1257278 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1257400 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 125000.0 | nM | - |
| CHEMBL31634 | BRIVUDINE | EC50 | > | 150000.0 | nM | - |