Assay Detail
Binding
CHEMBL1259664
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Inhibition of Wnt2/beta-casein signaling in human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Identification of 2,3,6-trisubstituted quinoxaline derivatives as a Wnt2/β-catenin pathway inhibitor in non-small-cell lung cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.60 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1257827 | — | — | 1 | 6.12 |
| CHEMBL1257944 | — | — | 1 | 6.04 |
| CHEMBL1257828 | — | — | 1 | 5.88 |
| CHEMBL1257943 | — | — | 1 | 5.79 |
| CHEMBL1258398 | — | — | 1 | 5.75 |
| CHEMBL1258171 | — | — | 1 | 5.72 |
| CHEMBL1258055 | — | — | 1 | 5.63 |
| CHEMBL460433 | CALPHOSTIN C | — | 1 | 5.50 |
| CHEMBL1258285 | — | — | 1 | 5.45 |
| CHEMBL1258054 | — | — | 1 | 5.42 |
| CHEMBL1258172 | — | — | 1 | 5.42 |
| CHEMBL1256408 | — | — | 1 | 5.32 |
| CHEMBL1257705 | — | — | 1 | 5.30 |
| CHEMBL1256409 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1257827 | — | IC50 | = | 758.0 | nM | 6.12 |
| CHEMBL1257944 | — | IC50 | = | 905.0 | nM | 6.04 |
| CHEMBL1257828 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL1257943 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL1258398 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL1258171 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL1258055 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL460433 | CALPHOSTIN C | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1258285 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL1258054 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1258172 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL1256408 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL1257705 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL1256409 | — | IC50 | = | 7900.0 | nM | 5.10 |