Assay Detail
Functional
CHEMBL1260087
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Antiviral activity against HIV1 NL4-3 infected in human Hut78 cells assessed as inhibition of viral replication in 50 % normal human serum
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Tissue | Serum |
| Cell Type | HuT78 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: selection of the scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.14 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1258278 | — | — | 1 | 8.40 |
| CHEMBL518520 | RALTEGRAVIR POTASSIUM | 4.0 | 1 | 8.15 |
| CHEMBL1258045 | — | — | 1 | 7.75 |
| CHEMBL1258162 | — | — | 1 | 7.40 |
| CHEMBL1258046 | — | — | 1 | 7.37 |
| CHEMBL1258163 | — | — | 1 | 7.37 |
| CHEMBL1257819 | — | — | 1 | 7.30 |
| CHEMBL1258277 | — | — | 1 | 7.21 |
| CHEMBL1257935 | — | — | 1 | 7.16 |
| CHEMBL1257936 | — | — | 1 | 6.80 |
| CHEMBL1257696 | — | — | 1 | 6.23 |
| CHEMBL1257575 | — | — | 1 | 5.85 |
| CHEMBL1257818 | — | — | 1 | 5.81 |
| CHEMBL1257580 | — | — | 1 | - |
| CHEMBL1257576 | — | — | 1 | - |
| CHEMBL1257697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1258278 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL518520 | RALTEGRAVIR POTASSIUM | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL1258045 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1258162 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1258046 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1258163 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1257819 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1258277 | — | EC50 | = | 61.5 | nM | 7.21 |
| CHEMBL1257935 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1257936 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL1257696 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1257575 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1257818 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL1257580 | — | EC50 | - | — | - | |
| CHEMBL1257576 | — | EC50 | - | — | - | |
| CHEMBL1257697 | — | EC50 | - | — | - |