Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1260089

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCV assessed as inhibition of viral replication by luciferase assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

7-O-Arylmethylgalangin as a novel scaffold for anti-HCV agents.
Lee HS, Park KS, Lee C, Lee B, Kim DE, Chong Y.
Bioorg Med Chem Lett (2010) 20 : 5709 -5712
PubMed 20797857 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 22 5.01 6.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL522710 1 6.09
CHEMBL1258409 1 6.05
CHEMBL1257842 1 5.70
CHEMBL1258410 1 5.52
CHEMBL1257841 1 5.52
CHEMBL1258518 1 5.22
CHEMBL1258297 1 5.22
CHEMBL1258069 1 5.22
CHEMBL1257598 1 5.16
CHEMBL1258068 1 5.10
CHEMBL1258185 1 5.00
CHEMBL1257368 1 5.00
CHEMBL1257957 1 4.82
CHEMBL1258184 1 4.72
CHEMBL1257717 1 4.66
CHEMBL1257477 1 4.60
CHEMBL1257956 1 4.57
CHEMBL1257367 1 4.52
CHEMBL1257718 1 4.43
CHEMBL1258298 1 4.42
CHEMBL1257476 1 4.41
CHEMBL1255594 1 4.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL522710 EC50 = 820.0 nM 6.09
CHEMBL1258409 EC50 = 900.0 nM 6.05
CHEMBL1257842 EC50 = 2000.0 nM 5.70
CHEMBL1258410 EC50 = 3000.0 nM 5.52
CHEMBL1257841 EC50 = 3000.0 nM 5.52
CHEMBL1258518 EC50 = 6000.0 nM 5.22
CHEMBL1258297 EC50 = 6000.0 nM 5.22
CHEMBL1258069 EC50 = 6000.0 nM 5.22
CHEMBL1257598 EC50 = 7000.0 nM 5.16
CHEMBL1258068 EC50 = 8000.0 nM 5.10
CHEMBL1258185 EC50 = 10000.0 nM 5.00
CHEMBL1257368 EC50 = 10000.0 nM 5.00
CHEMBL1257957 EC50 = 15000.0 nM 4.82
CHEMBL1258184 EC50 = 19000.0 nM 4.72
CHEMBL1257717 EC50 = 22000.0 nM 4.66
CHEMBL1257477 EC50 = 25000.0 nM 4.60
CHEMBL1257956 EC50 = 27000.0 nM 4.57
CHEMBL1257367 EC50 = 30000.0 nM 4.52
CHEMBL1257718 EC50 = 37000.0 nM 4.43
CHEMBL1258298 EC50 = 38000.0 nM 4.42
CHEMBL1257476 EC50 = 39000.0 nM 4.41
CHEMBL1255594 EC50 = 53000.0 nM 4.28