Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1260859

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against HEK293 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HEK293
Confidence 1 — Organism
Curated By Autocuration

Target

HEK293 (CHEMBL614818)
Type CELL-LINE
Organism Homo sapiens

Publication

3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity.
Ban K, Duffy S, Khakham Y, Avery VM, Hughes A, Montagnat O, Katneni K, Ryan E, Baell JB.
Bioorg Med Chem Lett (2010) 20 : 6024 -6029
PubMed 20822904 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 4.58 5.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1258236 1 5.05
CHEMBL1258237 1 4.80
CHEMBL599883 1 4.75
CHEMBL1255726 1 4.68
CHEMBL1255725 1 4.62
CHEMBL1258235 1 4.60
CHEMBL1256612 1 4.44
CHEMBL1255618 1 4.17
CHEMBL1255619 1 4.08
CHEMBL1255620 1 -
CHEMBL1258122 1 -
CHEMBL1255727 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1258236 EC50 = 9000.0 nM 5.05
CHEMBL1258237 EC50 = 16000.0 nM 4.80
CHEMBL599883 EC50 = 18000.0 nM 4.75
CHEMBL1255726 EC50 = 21000.0 nM 4.68
CHEMBL1255725 EC50 = 24000.0 nM 4.62
CHEMBL1258235 EC50 = 25000.0 nM 4.60
CHEMBL1256612 EC50 = 36000.0 nM 4.44
CHEMBL1255618 EC50 = 68000.0 nM 4.17
CHEMBL1255619 EC50 = 84000.0 nM 4.08
CHEMBL1255620 EC50 > 115000.0 nM -
CHEMBL1258122 EC50 > 115000.0 nM -
CHEMBL1255727 EC50 - -