Assay Detail

CHEMBL1262423

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Functional

Antiviral activity against vesicular stomatitis virus G-pseudotyped Human immunodeficiency virus infected in human MT-4 cells assessed as inhibition of viral replication

ChEMBL ↗

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Target

Human immunodeficiency virus (CHEMBL613758) ↗

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Primary target Human immunodeficiency virus

CHEMBL613758

Anchored from Assay target.

Protein identity Human immunodeficiency virus

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus
Cell Type	MT4
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus (CHEMBL613758) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus

Publication

The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.

Garvey EP, Johns BA, Gartland MJ, Foster SA, Miller WH, Ferris RG, Hazen RJ, Underwood MR, Boros EE, Thompson JB, Weatherhead JG, Koble CS, Allen SH, Schaller LT, Sherrill RG, Yoshinaga T, Kobayashi M, Wakasa-Morimoto C, Miki S, Nakahara K, Noshi T, Sato A, Fujiwara T.
Antimicrob Agents Chemother (2008) 52 : 901 -908
PubMed 18160521 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	4	8.78	9.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL204656	ELVITEGRAVIR	4.0	1	9.00
CHEMBL1256978	GSK-364735	2.0	1	8.77
CHEMBL254316	RALTEGRAVIR	4.0	1	8.70
CHEMBL414850	—	—	1	8.66

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL204656	ELVITEGRAVIR	EC50	=	1.0	nM	9.00
CHEMBL1256978	GSK-364735	EC50	=	1.7	nM	8.77
CHEMBL254316	RALTEGRAVIR	EC50	=	2.0	nM	8.70
CHEMBL414850	—	EC50	=	2.2	nM	8.66