Assay Detail
Binding
CHEMBL1262918
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Inhibition of death receptor signaling mediated necroptotic cell death in human Jurkat cell deficient in FADD assessed as cell viability after 30 hrs by ATP based viability assay in presence of TNFalpha
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.58 | 6.74 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382085 | — | — | 1 | 6.74 |
| CHEMBL381230 | — | — | 1 | 6.69 |
| CHEMBL195008 | NECROSTATIN | — | 2 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382085 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL381230 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL195008 | NECROSTATIN | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL195008 | NECROSTATIN | Inhibition | - | % | - |