Assay Detail
Functional
CHEMBL1263149
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Antiviral activity against HIV1 subtype B-92US076 infected in 1 hr-pretreated PBMC cells assessed as inhibition of p24 antigen production measured on day 5 postinfection by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Entecavir exhibits inhibitory activity against human immunodeficiency virus under conditions of reduced viral challenge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.98 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.52 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.10 |
| CHEMBL5314362 | ENTECAVIR | 4.0 | 1 | 7.21 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5314362 | ENTECAVIR | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 81.0 | nM | 7.09 |