Assay Detail

CHEMBL1263471

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Functional

Antiviral activity against 0.005 MOI HIV1 NL4-3 harboring M184V mutant RT infected in human MT2 cells

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Cell Type	MT2
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Entecavir exhibits inhibitory activity against human immunodeficiency virus under conditions of reduced viral challenge.

Lin PF, Nowicka-Sans B, Terry B, Zhang S, Wang C, Fan L, Dicker I, Gali V, Higley H, Parkin N, Tenney D, Krystal M, Colonno R.
Antimicrob Agents Chemother (2008) 52 : 1759 -1767
PubMed 18316521 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	4	9.00	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL223228	EFAVIRENZ	4.0	1	9.70
CHEMBL129	ZIDOVUDINE	4.0	1	8.30
CHEMBL5314362	ENTECAVIR	4.0	1	-
CHEMBL141	LAMIVUDINE	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL223228	EFAVIRENZ	EC50	=	0.2	nM	9.70
CHEMBL129	ZIDOVUDINE	EC50	=	5.0	nM	8.30
CHEMBL5314362	ENTECAVIR	EC50	>	10000.0	nM	-
CHEMBL141	LAMIVUDINE	EC50	>	10000.0	nM	-