Assay Detail
Functional
CHEMBL1263768
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV 1 subtype B harboring wild type reverse transcriptase infected in human TZM-bl cells assessed as inhibition of viral growth by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.30 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 9.04 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.90 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.45 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 0.91 | nM | 9.04 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 1.25 | nM | 8.90 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 3.57 | nM | 8.45 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 163.0 | nM | 6.79 |