Assay Detail
Functional
CHEMBL1264249
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Antiviral activity against wild-type HIV1 pNL4-3 infected in human MT4 cells assessed as reduction in viral cytopathogenicity after 5 days post dose by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.38 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470508 | — | — | 1 | 7.66 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 7.52 |
| CHEMBL222559 | TIPRANAVIR | 4.0 | 1 | 7.18 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 7.17 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470508 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL222559 | TIPRANAVIR | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1323 | DARUNAVIR | EC50 | > | 100.0 | nM | - |