Assay Detail
Binding
CHEMBL1265731
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Inhibition of Aeromonas enteropelogenes Beta-lactamase TRU1
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aeromonas enteropelogenes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Km | 5 | - | - |
| Ki | 2 | 6.20 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL702 | PIPERACILLIN | 4.0 | 1 | 6.70 |
| CHEMBL29 | PENICILLIN G | 4.0 | 1 | 5.70 |
| CHEMBL1730 | CEFOTAXIME | 4.0 | 1 | - |
| CHEMBL996 | CEFOXITIN | 4.0 | 1 | - |
| CHEMBL44354 | CEFTAZIDIME | 4.0 | 1 | - |
| CHEMBL161 | CEFTRIAXONE | 4.0 | 1 | - |
| CHEMBL1436 | CEFUROXIME | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL702 | PIPERACILLIN | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL29 | PENICILLIN G | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1730 | CEFOTAXIME | Km | = | 0.9 | nM | - |
| CHEMBL996 | CEFOXITIN | Km | = | 25.0 | nM | - |
| CHEMBL44354 | CEFTAZIDIME | Km | = | 120.0 | nM | - |
| CHEMBL161 | CEFTRIAXONE | Km | = | 6000.0 | nM | - |
| CHEMBL1436 | CEFUROXIME | Km | = | 1.1 | nM | - |