Assay Detail
Binding
CHEMBL1272385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MNK1 by Hot Spot filtration binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 1 (CHEMBL4718) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.78 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478629 | DORSOMORPHIN | — | 1 | 7.96 |
| CHEMBL1271532 | — | — | 1 | 7.57 |
| CHEMBL1271480 | — | — | 1 | 7.35 |
| CHEMBL324153 | — | — | 1 | 6.89 |
| CHEMBL1271533 | — | — | 1 | 6.79 |
| CHEMBL1271641 | — | — | 1 | 6.02 |
| CHEMBL1271692 | — | — | 1 | 5.96 |
| CHEMBL1271642 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478629 | DORSOMORPHIN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1271532 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1271480 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL324153 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1271533 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL1271641 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1271692 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1271642 | — | IC50 | = | 2200.0 | nM | 5.66 |