Assay Detail
Functional
CHEMBL1272809
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Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumour activity of glycyrrhetinic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.04 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269535 | — | — | 1 | 5.65 |
| CHEMBL1269521 | — | — | 1 | 5.56 |
| CHEMBL1269524 | — | — | 1 | 5.55 |
| CHEMBL1269536 | — | — | 1 | 5.37 |
| CHEMBL1269537 | — | — | 1 | 5.32 |
| CHEMBL1269527 | — | — | 1 | 5.30 |
| CHEMBL1269516 | — | — | 1 | 4.69 |
| CHEMBL1271536 | — | — | 1 | 4.67 |
| CHEMBL1271483 | — | — | 1 | 4.66 |
| CHEMBL1271592 | — | — | 1 | 4.58 |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269535 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL1269521 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL1269524 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL1269536 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL1269537 | — | IC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL1269527 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL1269516 | — | IC50 | = | 20570.0 | nM | 4.69 |
| CHEMBL1271536 | — | IC50 | = | 21580.0 | nM | 4.67 |
| CHEMBL1271483 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL1271592 | — | IC50 | = | 26440.0 | nM | 4.58 |
| CHEMBL230006 | ENOXOLONE | IC50 | = | 78830.0 | nM | 4.10 |