Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1273035

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CCRF-CEM cells after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel synthetic 2-amino-10-(3,5-dimethoxy)benzyl-9(10H)-acridinone derivatives as potent DNA-binding antiproliferative agents.
Gao C, Liu F, Luan X, Tan C, Liu H, Xie Y, Jin Y, Jiang Y.
Bioorg Med Chem (2010) 18 : 7507 -7514
PubMed 20863710 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.09 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1270695 1 6.55
CHEMBL1270903 1 6.41
CHEMBL1270696 1 6.22
CHEMBL1271209 1 6.21
CHEMBL1270902 1 6.19
CHEMBL1271002 1 6.17
CHEMBL520951 1 6.16
CHEMBL1270596 1 6.14
CHEMBL1271110 1 6.12
CHEMBL1271311 1 6.12
CHEMBL1271210 1 6.09
CHEMBL1270495 1 6.04
CHEMBL1270597 1 6.02
CHEMBL1271109 1 5.92
CHEMBL1271001 1 5.59
CHEMBL1270800 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1270695 IC50 = 280.0 nM 6.55
CHEMBL1270903 IC50 = 390.0 nM 6.41
CHEMBL1270696 IC50 = 600.0 nM 6.22
CHEMBL1271209 IC50 = 610.0 nM 6.21
CHEMBL1270902 IC50 = 640.0 nM 6.19
CHEMBL1271002 IC50 = 670.0 nM 6.17
CHEMBL520951 IC50 = 700.0 nM 6.16
CHEMBL1270596 IC50 = 720.0 nM 6.14
CHEMBL1271110 IC50 = 750.0 nM 6.12
CHEMBL1271311 IC50 = 750.0 nM 6.12
CHEMBL1271210 IC50 = 810.0 nM 6.09
CHEMBL1270495 IC50 = 910.0 nM 6.04
CHEMBL1270597 IC50 = 950.0 nM 6.02
CHEMBL1271109 IC50 = 1190.0 nM 5.92
CHEMBL1271001 IC50 = 2550.0 nM 5.59
CHEMBL1270800 IC50 = 3010.0 nM 5.52