Assay Detail
Functional
CHEMBL1273207
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated for 30 mins before LPS challenge measured after 24 hrs by Griess reagent method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.28 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269400 | — | — | 1 | 4.59 |
| CHEMBL1269426 | — | — | 1 | 4.25 |
| CHEMBL1269399 | — | — | 1 | 4.21 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.05 |
| CHEMBL1269349 | — | — | 1 | - |
| CHEMBL1269350 | — | — | 1 | - |
| CHEMBL1269398 | — | — | 1 | - |
| CHEMBL1269401 | — | — | 1 | - |
| CHEMBL1269425 | — | — | 1 | - |
| CHEMBL1269427 | — | — | 1 | - |
| CHEMBL1269428 | — | — | 1 | - |
| CHEMBL1269469 | — | — | 1 | - |
| CHEMBL1269470 | — | — | 1 | - |
| CHEMBL1269471 | — | — | 1 | - |
| CHEMBL1269472 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269400 | — | IC50 | = | 25750.0 | nM | 4.59 |
| CHEMBL1269426 | — | IC50 | = | 56870.0 | nM | 4.25 |
| CHEMBL1269399 | — | IC50 | = | 61980.0 | nM | 4.21 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 89410.0 | nM | 4.05 |
| CHEMBL1269349 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269350 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269398 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269401 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269425 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269427 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269428 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269469 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269470 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269471 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1269472 | — | IC50 | > | 100000.0 | nM | - |