Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1273257

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of factor 10a
ChEMBL ↗
128
Total Activities
126
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Coagulation factor X (CHEMBL244) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Factor Xa inhibitors: next-generation antithrombotic agents.
Pinto DJ, Smallheer JM, Cheney DL, Knabb RM, Wexler RR.
J Med Chem (2010) 53 : 6243 -6274
PubMed 20503967 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 87 8.62 10.89
IC50 41 8.28 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37251 — — 1 10.89
CHEMBL378093 — — 1 10.52
CHEMBL471725 — — 1 10.36
CHEMBL221906 — — 1 10.36
CHEMBL260085 — — 1 10.24
CHEMBL231779 APIXABAN 4.0 1 10.10
CHEMBL1270651 — — 1 10.00
CHEMBL474678 — — 1 10.00
CHEMBL73193 FIDEXABAN 2.0 1 10.00
CHEMBL512351 BETRIXABAN 4.0 1 9.92
CHEMBL414002 — — 1 9.89
CHEMBL140072 — — 1 9.82
CHEMBL176140 — — 1 9.82
CHEMBL1229814 — — 1 9.80
CHEMBL438647 — — 1 9.77
CHEMBL222079 — — 1 9.74
CHEMBL206335 RAZAXABAN 2.0 1 9.72
CHEMBL595475 — — 1 9.70
CHEMBL402109 — — 1 9.70
CHEMBL54237 — — 1 9.49
CHEMBL476186 ERIBAXABAN 2.0 1 9.49
CHEMBL1269832 — — 1 9.42
CHEMBL198362 RIVAROXABAN 4.0 2 9.40
CHEMBL233992 — — 1 9.37
CHEMBL593461 — — 1 9.30
CHEMBL46618 OTAMIXABAN 3.0 1 9.30
CHEMBL450578 — — 1 9.29
CHEMBL1271368 — — 1 9.26
CHEMBL1269025 EDOXABAN 4.0 1 9.25
CHEMBL1271369 — — 1 9.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37251 — Ki = 0.013 nM 10.89
CHEMBL378093 — Ki = 0.03 nM 10.52
CHEMBL221906 — Ki = 0.044 nM 10.36
CHEMBL471725 — Ki = 0.044 nM 10.36
CHEMBL260085 — Ki = 0.057 nM 10.24
CHEMBL231779 APIXABAN Ki = 0.08 nM 10.10
CHEMBL73193 FIDEXABAN Ki = 0.1 nM 10.00
CHEMBL474678 — IC50 = 0.1 nM 10.00
CHEMBL1270651 — Ki = 0.1 nM 10.00
CHEMBL512351 BETRIXABAN Ki = 0.12 nM 9.92
CHEMBL414002 — IC50 = 0.13 nM 9.89
CHEMBL176140 — Ki = 0.15 nM 9.82
CHEMBL140072 — Ki = 0.15 nM 9.82
CHEMBL1229814 — IC50 = 0.16 nM 9.80
CHEMBL438647 — Ki = 0.17 nM 9.77
CHEMBL222079 — Ki = 0.18 nM 9.74
CHEMBL206335 RAZAXABAN Ki = 0.19 nM 9.72
CHEMBL595475 — Ki = 0.2 nM 9.70
CHEMBL402109 — Ki = 0.2 nM 9.70
CHEMBL54237 — Ki = 0.32 nM 9.49
CHEMBL476186 ERIBAXABAN IC50 = 0.32 nM 9.49
CHEMBL1269832 — IC50 = 0.38 nM 9.42
CHEMBL198362 RIVAROXABAN Ki = 0.4 nM 9.40
CHEMBL233992 — Ki = 0.43 nM 9.37
CHEMBL593461 — Ki = 0.5 nM 9.30
CHEMBL46618 OTAMIXABAN Ki = 0.5 nM 9.30
CHEMBL450578 — Ki = 0.51 nM 9.29
CHEMBL1271368 — Ki = 0.55 nM 9.26
CHEMBL1269025 EDOXABAN Ki = 0.56 nM 9.25
CHEMBL1271369 — Ki = 0.6 nM 9.22
CHEMBL176243 — Ki = 0.6 nM 9.22
CHEMBL398380 — Ki = 0.67 nM 9.17
CHEMBL279486 — Ki = 0.7 nM 9.15
CHEMBL1271056 — Ki = 0.7 nM 9.15
CHEMBL198362 RIVAROXABAN IC50 = 0.7 nM 9.15
CHEMBL173650 — Ki = 0.8 nM 9.10
CHEMBL1270358 — IC50 = 0.83 nM 9.08
CHEMBL1271161 — Ki = 0.9 nM 9.05
CHEMBL151939 — Ki = 0.91 nM 9.04
CHEMBL1270158 — Ki = 0.97 nM 9.01
CHEMBL182597 — Ki = 1.0 nM 9.00
CHEMBL384526 — Ki = 1.1 nM 8.96
CHEMBL423417 — Ki = 1.1 nM 8.96
CHEMBL1269024 — IC50 = 1.2 nM 8.92
CHEMBL20240 YM-60828 Ki = 1.3 nM 8.89
CHEMBL369086 — Ki = 1.3 nM 8.89
CHEMBL279287 — Ki = 1.5 nM 8.82
CHEMBL367953 — Ki = 1.5 nM 8.82
CHEMBL463385 — Ki = 1.7 nM 8.77
CHEMBL1095032 LETAXABAN Ki = 1.8 nM 8.74