Assay Detail
Functional
CHEMBL1273408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Poliovirus infected in human HeLaS3 cells assessed as inhibition of viral replication treated 1 hr before infection measured after 2 days
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human enterovirus C |
| Cell Type | HeLa S3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.16 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269812 | — | — | 1 | 7.96 |
| CHEMBL267099 | TUBERCIDIN | — | 1 | 7.52 |
| CHEMBL1269736 | — | — | 1 | 6.00 |
| CHEMBL1269813 | — | — | 1 | - |
| CHEMBL1269814 | — | — | 1 | - |
| CHEMBL1269067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269812 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL267099 | TUBERCIDIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1269736 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL1269813 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1269814 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1269067 | — | IC50 | > | 10000.0 | nM | - |