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Assay Detail

CHEMBL1273722

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Candida albicans ATCC 10231 isocitrate lyase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Candida albicans
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Isocitrate lyase (CHEMBL5359)
Type SINGLE PROTEIN
Organism Candida albicans

Publication

Bromophenols as Candida albicans isocitrate lyase inhibitors.
Oh KB, Jeon HB, Han YR, Lee YJ, Park J, Lee SH, Yang D, Kwon M, Shin J, Lee HS.
Bioorg Med Chem Lett (2010) 20 : 6644 -6648
PubMed 20888765 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.67 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1269936 1 5.58
CHEMBL1269421 1 5.05
CHEMBL1269935 1 4.93
CHEMBL1270043 1 4.83
CHEMBL1270044 1 4.81
CHEMBL253690 1 4.73
CHEMBL1269460 1 4.67
CHEMBL1269420 1 4.65
CHEMBL491516 1 4.55
CHEMBL1269419 1 4.51
CHEMBL481708 1 4.34
CHEMBL451226 1 4.29
CHEMBL1269459 1 4.23
CHEMBL1269393 1 4.17
CHEMBL1269461 1 -
CHEMBL1269392 1 -
CHEMBL267345 AMPHOTERICIN B 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1269936 IC50 = 2650.0 nM 5.58
CHEMBL1269421 IC50 = 8890.0 nM 5.05
CHEMBL1269935 IC50 = 11630.0 nM 4.93
CHEMBL1270043 IC50 = 14770.0 nM 4.83
CHEMBL1270044 IC50 = 15610.0 nM 4.81
CHEMBL253690 IC50 = 18440.0 nM 4.73
CHEMBL1269460 IC50 = 21210.0 nM 4.67
CHEMBL1269420 IC50 = 22580.0 nM 4.65
CHEMBL491516 IC50 = 28060.0 nM 4.55
CHEMBL1269419 IC50 = 30880.0 nM 4.51
CHEMBL481708 IC50 = 46150.0 nM 4.34
CHEMBL451226 IC50 = 50700.0 nM 4.29
CHEMBL1269459 IC50 = 58470.0 nM 4.23
CHEMBL1269393 IC50 = 68190.0 nM 4.17
CHEMBL1269461 IC50 > 100.0 ug.mL-1 -
CHEMBL1269392 IC50 > 100000.0 nM -
CHEMBL267345 AMPHOTERICIN B IC50 - -