Assay Detail
Binding
CHEMBL1274063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vesicular acetylcholine transporter (CHEMBL2125) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.81 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1271961 | — | — | 1 | 8.43 |
| CHEMBL1271907 | — | — | 1 | 8.16 |
| CHEMBL1271906 | — | — | 1 | 7.96 |
| CHEMBL65239 | — | — | 1 | 7.80 |
| CHEMBL1271793 | — | — | 1 | 7.71 |
| CHEMBL277630 | — | — | 1 | 7.39 |
| CHEMBL1271850 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1271961 | — | Ki | = | 3.68 | nM | 8.43 |
| CHEMBL1271907 | — | Ki | = | 6.95 | nM | 8.16 |
| CHEMBL1271906 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL65239 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL1271793 | — | Ki | = | 19.6 | nM | 7.71 |
| CHEMBL277630 | — | Ki | = | 40.6 | nM | 7.39 |
| CHEMBL1271850 | — | Ki | = | 56.9 | nM | 7.25 |