Assay Detail
Binding
CHEMBL1278933
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Inhibition of methicillin-resistant Staphylococcus aureus COL PBP2a by competitive assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus subsp. aureus COL |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.50 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520642 | CEFTOBIPROLE | 2.0 | 1 | 5.50 |
| CHEMBL819 | OXACILLIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520642 | CEFTOBIPROLE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL819 | OXACILLIN | IC50 | = | 710000.0 | nM | - |