Compound Detail
CHEMBL819
OXACILLIN 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Cc1onc(-c2ccccc2)c1C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O
Basic Information
| ChEMBL ID | CHEMBL819 |
| Name | OXACILLIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | UWYHMGVUTGAWSP-JKIFEVAISA-N |
| Therapeutic | ✓ Yes |
1
Targets
7
Activities
2
Assay Types
8
PK Parameters
20
Publications
4
Known Names
5
Indications
Molecular Properties
401.4
MW (Da)
1.90
ALogP
6
HBA
2
HBD
112.7
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1971 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections Bacteremia Gram-Positive Bacterial Infections Osteomyelitis Infections
ATC Classification
J01CF04
oxacillin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
Ki 5 meas.
IC50 2 meas. best 4.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Organic anion transporter 3 CHEMBL2073672 | IC50 | 4.46 | 4.46 | 35000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 6.3 | mL.min-1.kg-1 | Homo sapiens |
| CL | 6.3 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 159426.07 | nM | Homo sapiens |
| F | 49.0 | % | Homo sapiens |
| Fu | 0.07 | - | Homo sapiens |
| Fu | 0.07 | - | Homo sapiens |
| MRT | 0.5 | hr | Homo sapiens |
| T1/2 | 0.7 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Organic anion transporter 3 | IC50 | = | 35000.0 | nM | 4.46 | Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluore... | 23344796 |
Literature References
Data from ChEMBL 36 via Core Engine