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Target Snapshot

CHEMBL2073672 Target Snapshot

Organic anion transporter 3 · SINGLE PROTEIN · Mus musculus

58Compounds
33Assays
9Approved Drugs
13.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt O88909. Use UniProt O88909 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O88909 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Organic anion transporter 3 as ChEMBL target CHEMBL2073672, mapped to UniProt O88909. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Organic anion transporter 3
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2073672
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O88909
Organic anion transporter 3
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Organic anion transporter 3 is the right protein anchor across sources, using UniProt O88909 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelOrganic anion transporter 3
UniProt AccessionO88909
Component TypeProtein
Sequence Length537 aa

Organic anion transporter 3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Organic anion transporter 3, mapped to UniProt O88909. Sequence length is 537 aa.

Mapped IDO88909
Review nameOrganic anion transporter 3
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

9
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5013.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL897 5.52 IC50 3020.0 Approved
CHEMBL893 4.78 IC50 16600.0 Approved
CHEMBL891 4.51 IC50 30900.0 Approved
CHEMBL617 4.48 IC50 33300.0 Approved
CHEMBL819 4.46 IC50 35000.0 Approved
CHEMBL1443 4.46 IC50 34900.0 Approved
CHEMBL222913 4.45 IC50 35700.0 Clinical
CHEMBL615 4.31 IC50 48600.0 Approved
CHEMBL996 4.24 IC50 57000.0 Approved
CHEMBL29 4.05 IC50 89400.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

33
Total Assays
13
Tested Compounds
2
Assay Types
Functional — 25 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 25 0
ADME — 8 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 13 4.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine