Compound Detail
CHEMBL1443
NAFCILLIN 💊 Approved Drug
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💊 Approved Drug
CCOc1ccc2ccccc2c1C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O
Basic Information
| ChEMBL ID | CHEMBL1443 |
| Name | NAFCILLIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | GPXLMGHLHQJAGZ-JTDSTZFVSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
6
PK Parameters
20
Publications
3
Known Names
5
Indications
Molecular Properties
414.5
MW (Da)
2.48
ALogP
5
HBA
2
HBD
95.9
PSA (Ų)
0.73
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1965 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections Osteomyelitis Bacteremia Gram-Positive Bacterial Infections Infections
ATC Classification
J01CF06
nafcillin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
IC50 1 meas. best 4.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Organic anion transporter 3 CHEMBL2073672 | IC50 | 4.46 | 4.46 | 34900.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 3.3 | mL.min-1.kg-1 | Homo sapiens |
| CL | 3.3 | mL.min-1.kg-1 | Homo sapiens |
| F | 49.0 | % | Homo sapiens |
| Fu | 0.13 | - | Homo sapiens |
| MRT | 1.1 | hr | Homo sapiens |
| T1/2 | 0.7 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Organic anion transporter 3 | IC50 | = | 34900.0 | nM | 4.46 | Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluore... | 23344796 |
Literature References
Data from ChEMBL 36 via Core Engine