Compound Detail
CHEMBL617
CEPHALOTHIN 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL617 |
| Name | CEPHALOTHIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XIURVHNZVLADCM-IUODEOHRSA-N |
| Therapeutic | ✓ Yes |
8
Targets
16
Activities
2
Assay Types
18
PK Parameters
20
Publications
3
Known Names
1
Indications
Molecular Properties
396.4
MW (Da)
0.59
ALogP
7
HBA
2
HBD
113.0
PSA (Ų)
0.53
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1974 |
| Availability | Discontinued |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections
ATC Classification
J01DB03
cefalotin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
Ki 11 meas. best 7.4
IC50 5 meas. best 5.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Organic anion transporter 3 CHEMBL1641348 | Ki | 7.4 | 7.4 | 40.0 | 1 |
| Solute carrier family 22 member 11 CHEMBL2073677 | Ki | 6.7 | 6.7 | 200.0 | 1 |
| Solute carrier family 22 member 6 CHEMBL1641347 | Ki | 6.66 | 6.66 | 220.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 6.5 | 6.5 | 320.0 | 2 |
| Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 CHEMBL1795098 | IC50 | 5.55 | 5.55 | 2786.0 | 1 |
| DNA (cytosine-5)-methyltransferase 1 CHEMBL1993 | IC50 | 5.14 | 5.14 | 7280.0 | 1 |
| Organic anion transporter 3 CHEMBL2073672 | IC50 | 4.48 | 4.48 | 33300.0 | 1 |
| Organic anion transporter 3 CHEMBL2073666 | Ki | 4.32 | 4.32 | 48000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 12050.0 | ng.hr.mL-1 | Homo sapiens |
| AUC | 9890.0 | ng.hr.mL-1 | Homo sapiens |
| CL | 1.8 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 97616.35 | nM | Homo sapiens |
| Cmax | 53726.83 | nM | Homo sapiens |
| Fu | 0.22 | - | Homo sapiens |
| MRT | 0.65 | hr | Homo sapiens |
| MRT | 0.59 | hr | Homo sapiens |
| MRT | 0.38 | hr | Homo sapiens |
| T1/2 | 29.0 | hr | - |
| T1/2 | 1.1 | hr | - |
| T1/2 | 0.95 | hr | Homo sapiens |
| T1/2 | 0.41 | hr | Homo sapiens |
| T1/2 | 0.26 | hr | Homo sapiens |
| T1/2 | 0.91 | hr | Homo sapiens |
| T1/2 | 0.74 | hr | Homo sapiens |
| Vz | 1.19 | L/hr/kg | Homo sapiens |
| Vz | 1.58 | L/hr/kg | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine