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Target Snapshot

CHEMBL1641347 Target Snapshot

Solute carrier family 22 member 6 · SINGLE PROTEIN · Homo sapiens

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143Compounds
151Assays
24Approved Drugs
103.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Solute carrier family 22 member 6 shows approved-linked disease relevance led by gout. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q4U2R8. Start with gout, then reuse UniProt Q4U2R8 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with gout, then reuse UniProt Q4U2R8 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
gout

Solute carrier family 22 member 6 shows approved-linked disease relevance led by gout. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with gout because it currently carries approved-linked support. Linked drugs include PROBENECID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Solute carrier family 22 member 6 as ChEMBL target CHEMBL1641347, mapped to UniProt Q4U2R8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Solute carrier family 22 member 6
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1641347
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q4U2R8
Solute carrier family 22 member 6
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Solute carrier family 22 member 6 is the right protein anchor across sources, using UniProt Q4U2R8 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why gout is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSolute carrier family 22 member 6
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ4U2R8
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSolute carrier family 22 member 6
UniProt AccessionQ4U2R8
Component TypeProtein
Sequence Length563 aa

Solute carrier family 22 member 6

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Solute carrier family 22 member 6, mapped to UniProt Q4U2R8. Sequence length is 563 aa.

Mapped IDQ4U2R8
Review nameSolute carrier family 22 member 6
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Solute carrier family 22 member 6 shows approved-linked disease relevance led by gout. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
gout
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
cystitis
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
infection
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
male infertility
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
obesity
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
urinary tract infection
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with gout because it currently carries approved-linked support. Linked drugs include PROBENECID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasegout
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

24
Approved
3
Phase III
6
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5073.0
KI30.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1146 7.52 Ki 30.0 Clinical
CHEMBL1435 6.75 Ki 180.0 Approved
CHEMBL507674 6.68 Ki 210.0 Approved
CHEMBL617 6.66 Ki 220.0 Approved
CHEMBL161 6.64 Ki 230.0 Approved
CHEMBL6246 6.57 IC50 270.0 Clinical
CHEMBL316157 6.13 Ki 740.0 Approved
CHEMBL898 6.07 IC50 850.0 Approved
CHEMBL571 5.89 IC50 1300.0 Approved
CHEMBL563 5.82 IC50 1500.0 Approved
Distribution

pChEMBL Value Distribution

25
5.0
7
5.5
2
6.0
5
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CEFTRIAXONE
CHEMBL161
Approved 1984
Properties Compare Identifier
CEFOPERAZONE
CHEMBL507674
Approved 1982
Properties Compare Identifier
DIFLUNISAL
CHEMBL898
Approved 1982
Properties Compare Identifier
CEPHALOTHIN
CHEMBL617
Approved 1974
Properties Compare Identifier
CEFAZOLIN
CHEMBL1435
Approved 1973
Properties Compare Identifier
CEPHALORIDINE
CHEMBL316157
Properties Compare Identifier
Assay Landscape

Assay Landscape

153
Total Assays
46
Tested Compounds
4
Assay Types
Functional — 94 assays, 46 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 93 46 5.2
assay format 1 0 —
Binding — 36 assays, 26 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 21 10 4.9
cell-based format 15 16 4.9
ADME — 22 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 2 4.9
single protein format 7 1 —
Toxicity — 1 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 4 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine