Compound Detail
CHEMBL316157
CEPHALORIDINE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
O=C(Cc1cccs1)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12
Basic Information
| ChEMBL ID | CHEMBL316157 |
| Name | CEPHALORIDINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | CZTQZXZIADLWOZ-CRAIPNDOSA-N |
5
Targets
13
Activities
3
Assay Types
4
PK Parameters
20
Publications
4
Known Names
1
Indications
Molecular Properties
415.5
MW (Da)
-0.32
ALogP
6
HBA
1
HBD
93.4
PSA (Ų)
0.52
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Withdrawn |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections
ATC Classification
J01DB02
cefaloridine
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Drug Warnings
Withdrawn
nephrotoxicity
Nephrotoxicity
Activity Summary
Ki 9 meas. best 6.13
IC50 3 meas.
EC50 1 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 22 member 6 CHEMBL1641347 | Ki | 6.13 | 6.13 | 740.0 | 1 |
| Organic anion transporter 3 CHEMBL1641348 | Ki | 5.61 | 5.61 | 2460.0 | 1 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL3401 | EC50 | 5.5 | 5.5 | 3200.0 | 1 |
| Solute carrier family 22 member 11 CHEMBL2073677 | Ki | 5.44 | 5.44 | 3630.0 | 1 |
| Solute carrier family 15 member 2 CHEMBL3325 | Ki | 5.07 | 5.07 | 8500.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 3.3 | mL.min-1.kg-1 | Homo sapiens |
| Fu | 0.8 | - | Homo sapiens |
| MRT | 2.3 | hr | Homo sapiens |
| T1/2 | 1.5 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 6 | Ki | = | 740.0 | nM | 6.13 | TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells | 11909604 |
| Organic anion transporter 3 | Ki | = | 2460.0 | nM | 5.61 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells | 11909604 |
| Nuclear receptor subfamily 1 group I member 2 | EC50 | = | 3200.0 | nM | 5.5 | Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay | 20966043 |
| Solute carrier family 22 member 11 | Ki | = | 3630.0 | nM | 5.44 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT4-expressing S2 cells | 11909604 |
| Solute carrier family 15 member 2 | Ki | = | 8500.0 | nM | 5.07 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells | 15567297 |
Literature References
Data from ChEMBL 36 via Core Engine