Assay Detail
Functional
CHEMBL2078490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT4-expressing S2 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | S2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 11 (CHEMBL2073677) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Interaction of human organic anion transporters with various cephalosporin antibiotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.75 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL617 | CEPHALOTHIN | 4.0 | 1 | 6.70 |
| CHEMBL1146 | CEFAMANDOLE | 2.0 | 1 | 5.94 |
| CHEMBL1435 | CEFAZOLIN | 4.0 | 1 | 5.76 |
| CHEMBL161 | CEFTRIAXONE | 4.0 | 1 | 5.62 |
| CHEMBL507674 | CEFOPERAZONE | 4.0 | 1 | 5.55 |
| CHEMBL316157 | CEPHALORIDINE | 4.0 | 1 | 5.44 |
| CHEMBL1730 | CEFOTAXIME | 4.0 | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL617 | CEPHALOTHIN | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1146 | CEFAMANDOLE | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL1435 | CEFAZOLIN | Ki | = | 1740.0 | nM | 5.76 |
| CHEMBL161 | CEFTRIAXONE | Ki | = | 2380.0 | nM | 5.62 |
| CHEMBL507674 | CEFOPERAZONE | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL316157 | CEPHALORIDINE | Ki | = | 3630.0 | nM | 5.44 |
| CHEMBL1730 | CEFOTAXIME | Ki | = | 6150.0 | nM | 5.21 |