Compound Detail
CHEMBL1435
CEFAZOLIN 💊 Approved Drug
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💊 Approved Drug
Cc1nnc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)Cn4cnnn4)[C@H]3SC2)s1
Basic Information
| ChEMBL ID | CHEMBL1435 |
| Name | CEFAZOLIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | MLYYVTUWGNIJIB-BXKDBHETSA-N |
| Therapeutic | ✓ Yes |
3
Targets
6
Activities
1
Assay Types
21
PK Parameters
20
Publications
4
Known Names
16
Indications
Molecular Properties
454.5
MW (Da)
-0.64
ALogP
12
HBA
2
HBD
156.1
PSA (Ų)
0.41
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1973 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections Arrhythmias, Cardiac Bacteremia Cellulitis Clostridium Infections Gram-Positive Bacterial Infections Infections Laryngeal Neoplasms Osteomyelitis Prostatic Neoplasms, Castration-Resistant Skin Diseases Staphylococcal Infections Fractures, Bone Wounds and Injuries Melanoma Obesity
ATC Classification
J01DB04
cefazolin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
Ki 6 meas. best 6.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 22 member 6 CHEMBL1641347 | Ki | 6.75 | 6.75 | 180.0 | 1 |
| Organic anion transporter 3 CHEMBL1641348 | Ki | 6.26 | 6.26 | 550.0 | 1 |
| Solute carrier family 22 member 11 CHEMBL2073677 | Ki | 5.76 | 5.76 | 1740.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 0.89 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.1 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.89 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.88 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.89 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.9 | mL.min-1.kg-1 | Macaca |
| CL | 3.5 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 6.7 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 0.066 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 11.24 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 0.007 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.001 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.4 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 0.089 | mL.min-1.kg-1 | Canis lupus familiaris |
| F | 90.0 | % | Homo sapiens |
| Fu | 0.18 | - | Homo sapiens |
| Fu | 0.18 | - | Homo sapiens |
| MRT | 2.2 | hr | Homo sapiens |
| T1/2 | 0.2333 | hr | Mus musculus |
| T1/2 | 1.7 | hr | Homo sapiens |
| Tmax | 0.125 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 6 | Ki | = | 180.0 | nM | 6.75 | TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells | 11909604 |
| Organic anion transporter 3 | Ki | = | 550.0 | nM | 6.26 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells | 11909604 |
| Solute carrier family 22 member 11 | Ki | = | 1740.0 | nM | 5.76 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT4-expressing S2 cells | 11909604 |
Literature References
Data from ChEMBL 36 via Core Engine