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Target Snapshot

CHEMBL1641348 Target Snapshot

Organic anion transporter 3 · SINGLE PROTEIN · Homo sapiens

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149Compounds
107Assays
17Approved Drugs
68.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Organic anion transporter 3 shows approved-linked disease relevance led by gout. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q8TCC7. Start with gout, then reuse UniProt Q8TCC7 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with gout, then reuse UniProt Q8TCC7 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
gout

Organic anion transporter 3 shows approved-linked disease relevance led by gout. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with gout because it currently carries approved-linked support. Linked drugs include PROBENECID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Organic anion transporter 3 as ChEMBL target CHEMBL1641348, mapped to UniProt Q8TCC7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Organic anion transporter 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1641348
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q8TCC7
Organic anion transporter 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Organic anion transporter 3 is the right protein anchor across sources, using UniProt Q8TCC7 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why gout is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameOrganic anion transporter 3
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ8TCC7
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelOrganic anion transporter 3
UniProt AccessionQ8TCC7
Component TypeProtein
Sequence Length542 aa

Organic anion transporter 3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Organic anion transporter 3, mapped to UniProt Q8TCC7. Sequence length is 542 aa.

Mapped IDQ8TCC7
Review nameOrganic anion transporter 3
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Organic anion transporter 3 shows approved-linked disease relevance led by gout. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
gout
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
cystitis
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
infection
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
male infertility
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
obesity
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Late clinical Phase III
urinary tract infection
1 linked drug · 1 direct · 1 efficacy
Linked drugPROBENECID
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with gout because it currently carries approved-linked support. Linked drugs include PROBENECID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasegout
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

17
Approved
2
Phase III
5
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5034.0
KI34.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL617 7.4 Ki 40.0 Approved
CHEMBL1146 7.34 Ki 46.0 Clinical
CHEMBL1730 6.54 Ki 290.0 Approved
CHEMBL3688197 6.3 IC50 500.0 Preclinical
CHEMBL1435 6.26 Ki 550.0 Approved
CHEMBL3683287 6.14 IC50 720.0 Preclinical
CHEMBL4519013 5.96 IC50 1100.0 Preclinical
CHEMBL4562825 5.96 IC50 1100.0 Preclinical
CHEMBL4584575 5.89 IC50 1300.0 Preclinical
CHEMBL507674 5.72 Ki 1890.0 Approved
Distribution

pChEMBL Value Distribution

18
5.0
8
5.5
3
6.0
1
6.5
2
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CEFOTAXIME
CHEMBL1730
Approved 1981
Properties Compare Identifier
CEPHALOTHIN
CHEMBL617
Approved 1974
Properties Compare Identifier
CEFAZOLIN
CHEMBL1435
Approved 1973
Properties Compare Identifier
Assay Landscape

Assay Landscape

107
Total Assays
29
Tested Compounds
3
Assay Types
Functional — 55 assays, 29 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 55 29 5.2
Binding — 28 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 17 9 5.5
cell-based format 11 12 5.2
ADME — 24 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 16 0 —
single protein format 8 2 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine