Assay Detail
Functional
CHEMBL2078140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | S2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Interaction of human organic anion transporters with various cephalosporin antibiotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.16 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL617 | CEPHALOTHIN | 4.0 | 1 | 7.40 |
| CHEMBL1146 | CEFAMANDOLE | 2.0 | 1 | 7.34 |
| CHEMBL1730 | CEFOTAXIME | 4.0 | 1 | 6.54 |
| CHEMBL1435 | CEFAZOLIN | 4.0 | 1 | 6.26 |
| CHEMBL507674 | CEFOPERAZONE | 4.0 | 1 | 5.72 |
| CHEMBL316157 | CEPHALORIDINE | 4.0 | 1 | 5.61 |
| CHEMBL161 | CEFTRIAXONE | 4.0 | 1 | 5.36 |
| CHEMBL1644 | CEFADROXIL | 4.0 | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL617 | CEPHALOTHIN | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL1146 | CEFAMANDOLE | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL1730 | CEFOTAXIME | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL1435 | CEFAZOLIN | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL507674 | CEFOPERAZONE | Ki | = | 1890.0 | nM | 5.72 |
| CHEMBL316157 | CEPHALORIDINE | Ki | = | 2460.0 | nM | 5.61 |
| CHEMBL161 | CEFTRIAXONE | Ki | = | 4390.0 | nM | 5.36 |
| CHEMBL1644 | CEFADROXIL | Ki | = | 8620.0 | nM | 5.06 |