Assay Detail
Functional
CHEMBL2078144
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | S2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 6 (CHEMBL1641347) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Interaction of human organic anion transporters with various cephalosporin antibiotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.39 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1146 | CEFAMANDOLE | 2.0 | 1 | 7.52 |
| CHEMBL1435 | CEFAZOLIN | 4.0 | 1 | 6.75 |
| CHEMBL507674 | CEFOPERAZONE | 4.0 | 1 | 6.68 |
| CHEMBL617 | CEPHALOTHIN | 4.0 | 1 | 6.66 |
| CHEMBL161 | CEFTRIAXONE | 4.0 | 1 | 6.64 |
| CHEMBL316157 | CEPHALORIDINE | 4.0 | 1 | 6.13 |
| CHEMBL1730 | CEFOTAXIME | 4.0 | 1 | 5.50 |
| CHEMBL1644 | CEFADROXIL | 4.0 | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1146 | CEFAMANDOLE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1435 | CEFAZOLIN | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL507674 | CEFOPERAZONE | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL617 | CEPHALOTHIN | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL161 | CEFTRIAXONE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL316157 | CEPHALORIDINE | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL1730 | CEFOTAXIME | Ki | = | 3130.0 | nM | 5.50 |
| CHEMBL1644 | CEFADROXIL | Ki | = | 6140.0 | nM | 5.21 |