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Target Snapshot

CHEMBL3325 Target Snapshot

Solute carrier family 15 member 2 · SINGLE PROTEIN · Rattus norvegicus

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86Compounds
42Assays
9Approved Drugs
81.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q63424. Use UniProt Q63424 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q63424 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Solute carrier family 15 member 2 as ChEMBL target CHEMBL3325, mapped to UniProt Q63424. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Solute carrier family 15 member 2
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL3325
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q63424
Solute carrier family 15 member 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Solute carrier family 15 member 2 is the right protein anchor across sources, using UniProt Q63424 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSolute carrier family 15 member 2
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtQ63424
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSolute carrier family 15 member 2
UniProt AccessionQ63424
Component TypeProtein
Sequence Length729 aa

Solute carrier family 15 member 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Solute carrier family 15 member 2, mapped to UniProt Q63424. Sequence length is 729 aa.

Mapped IDQ63424
Review nameSolute carrier family 15 member 2
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

9
Approved
1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC504.0
KI77.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1644 5.52 Ki 3000.0 Approved
CHEMBL214174 5.43 Ki 3700.0 Preclinical
CHEMBL188866 5.4 Ki 4000.0 Preclinical
CHEMBL56119 5.22 Ki 6000.0 Preclinical
CHEMBL299759 5.16 Ki 7000.0 Preclinical
CHEMBL417979 5.16 Ki 7000.0 Preclinical
CHEMBL472 5.11 Ki 7800.0 Approved
CHEMBL299889 5.1 Ki 8000.0 Preclinical
CHEMBL55636 5.1 Ki 8000.0 Preclinical
CHEMBL316157 5.07 Ki 8500.0 Approved
Distribution

pChEMBL Value Distribution

9
5.0
2
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

42
Total Assays
59
Tested Compounds
2
Assay Types
Functional — 41 assays, 59 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 41 59 4.6
Binding — 1 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 3 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine