Assay Detail
Functional
CHEMBL2076201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | SKPT |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 15 member 2 (CHEMBL3325) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 4.55 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644 | CEFADROXIL | 4.0 | 1 | 5.52 |
| CHEMBL316157 | CEPHALORIDINE | 4.0 | 1 | 5.07 |
| CHEMBL680 | CEFACLOR ANHYDROUS | 4.0 | 1 | 4.54 |
| CHEMBL1200356 | CYCLACILLIN | 4.0 | 1 | 4.36 |
| CHEMBL1604 | CEPHRADINE | 4.0 | 1 | 4.19 |
| CHEMBL1727 | CEPHALEXIN ANHYDROUS | 4.0 | 1 | 4.12 |
| CHEMBL74632 | MOXALACTAM | 4.0 | 1 | 4.06 |
| CHEMBL3351077 | CEFSULODIN | 2.0 | 1 | - |
| CHEMBL65794 | CEFPIROME | 2.0 | 1 | - |
| CHEMBL161 | CEFTRIAXONE | 4.0 | 1 | - |
| CHEMBL1599 | CEPHAPIRIN | 4.0 | 1 | - |
| CHEMBL44354 | CEFTAZIDIME | 4.0 | 1 | - |
| CHEMBL1730 | CEFOTAXIME | 4.0 | 1 | - |
| CHEMBL1236749 | — | — | 1 | - |
| CHEMBL186 | CEFEPIME | 4.0 | 1 | - |
| CHEMBL29 | PENICILLIN G | 4.0 | 1 | - |
| CHEMBL1436 | CEFUROXIME | 4.0 | 2 | - |
| CHEMBL891 | CLOXACILLIN | 4.0 | 1 | - |
| CHEMBL174 | AMPICILLIN | 4.0 | 1 | - |
| CHEMBL1541 | CEFIXIME | 4.0 | 1 | - |
| CHEMBL1146 | CEFAMANDOLE | 2.0 | 1 | - |
| CHEMBL2303613 | CEFODIZIME | 2.0 | 1 | - |
| CHEMBL819 | OXACILLIN | 4.0 | 1 | - |
| CHEMBL893 | DICLOXACILLIN | 4.0 | 1 | - |
| CHEMBL1201195 | CEFMETAZOLE | 4.0 | 1 | - |
| CHEMBL1082 | AMOXICILLIN | 4.0 | 1 | - |
| CHEMBL1615585 | — | — | 1 | - |
| CHEMBL1908324 | METAMPICILLIN | 2.0 | 1 | - |
| CHEMBL617 | CEPHALOTHIN | 4.0 | 1 | - |
| CHEMBL1605 | CEFTIBUTEN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644 | CEFADROXIL | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL316157 | CEPHALORIDINE | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL680 | CEFACLOR ANHYDROUS | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL1200356 | CYCLACILLIN | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL1604 | CEPHRADINE | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL1727 | CEPHALEXIN ANHYDROUS | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL74632 | MOXALACTAM | Ki | = | 87000.0 | nM | 4.06 |
| CHEMBL3351077 | CEFSULODIN | Ki | > | 30000000.0 | nM | - |
| CHEMBL65794 | CEFPIROME | Ki | = | 9500000.0 | nM | - |
| CHEMBL161 | CEFTRIAXONE | Ki | > | 20000000.0 | nM | - |
| CHEMBL1599 | CEPHAPIRIN | Ki | > | 10000000.0 | nM | - |
| CHEMBL44354 | CEFTAZIDIME | Ki | > | 10000000.0 | nM | - |
| CHEMBL1730 | CEFOTAXIME | Ki | = | 20000000.0 | nM | - |
| CHEMBL1236749 | — | Ki | = | 19000000.0 | nM | - |
| CHEMBL1436 | CEFUROXIME | Ki | = | 12600000.0 | nM | - |
| CHEMBL186 | CEFEPIME | Ki | = | 11400000.0 | nM | - |
| CHEMBL29 | PENICILLIN G | Ki | = | 11100000.0 | nM | - |
| CHEMBL1436 | CEFUROXIME | Ki | > | 3000.0 | nM | - |
| CHEMBL891 | CLOXACILLIN | Ki | = | 950000.0 | nM | - |
| CHEMBL174 | AMPICILLIN | Ki | = | 1300000.0 | nM | - |
| CHEMBL1541 | CEFIXIME | Ki | = | 2600000.0 | nM | - |
| CHEMBL2303613 | CEFODIZIME | Ki | = | 9000000.0 | nM | - |
| CHEMBL1605 | CEFTIBUTEN | Ki | = | 280000.0 | nM | - |
| CHEMBL819 | OXACILLIN | Ki | = | 3300000.0 | nM | - |
| CHEMBL893 | DICLOXACILLIN | Ki | = | 420000.0 | nM | - |
| CHEMBL1201195 | CEFMETAZOLE | Ki | = | 4300000.0 | nM | - |
| CHEMBL1082 | AMOXICILLIN | Ki | = | 430000.0 | nM | - |
| CHEMBL1615585 | — | Ki | = | 4900000.0 | nM | - |
| CHEMBL1908324 | METAMPICILLIN | Ki | = | 730000.0 | nM | - |
| CHEMBL617 | CEPHALOTHIN | Ki | = | 8300000.0 | nM | - |
| CHEMBL1146 | CEFAMANDOLE | Ki | = | 2800000.0 | nM | - |