Compound Detail
CHEMBL1605
CEFTIBUTEN 💊 Approved Drug
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💊 Approved Drug
Nc1nc(/C(=C/CC(=O)O)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=CCS[C@H]23)cs1
Basic Information
| ChEMBL ID | CHEMBL1605 |
| Name | CEFTIBUTEN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | UNJFKXSSGBWRBZ-BJCIPQKHSA-N |
| Therapeutic | ✓ Yes |
1
Targets
9
Activities
1
Assay Types
3
PK Parameters
20
Publications
13
Known Names
3
Indications
1
Mechanisms
Molecular Properties
410.4
MW (Da)
-0.05
ALogP
8
HBA
4
HBD
162.9
PSA (Ų)
0.37
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1995 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Bacterial penicillin-binding protein inhibitor | INHIBITOR | Bacterial penicillin-binding protein | ✓ | ✓ |
Indications
Bacterial Infections Pyelonephritis Osteomyelitis
ATC Classification
J01DD14
ceftibuten
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
Ki 9 meas. best 4.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 15 member 2 CHEMBL1743125 | Ki | 4.05 | 4.05 | 90000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 36547.04 | nM | Homo sapiens |
| F | 80.0 | % | Homo sapiens |
| T1/2 | 2.4 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier family 15 member 2 | Ki | = | 90000.0 | nM | 4.05 | TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing HeLa cells | 9092716 |
Literature References
Data from ChEMBL 36 via Core Engine