Assay Detail
Binding
CHEMBL1282385
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Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.22 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276635 | — | — | 1 | 5.92 |
| CHEMBL1276667 | — | — | 1 | 5.77 |
| CHEMBL1276666 | — | — | 1 | 5.37 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 4.55 |
| CHEMBL1276697 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276635 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1276667 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1276666 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1276697 | — | IC50 | = | 31000.0 | nM | 4.51 |