Compound Detail
CHEMBL1276667
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1276667 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WYDSOLLGSBEWGV-LLVKDONJSA-N |
3
Targets
7
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
346.4
MW (Da)
1.90
ALogP
6
HBA
1
HBD
73.3
PSA (Ų)
0.86
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 6.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.06 | 5.7667 | 880.0 | 3 |
| DNA gyrase subunit A CHEMBL1858 | IC50 | 5.92 | 5.7033 | 1200.0 | 3 |
| DNA gyrase CHEMBL3038482 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 880.0 | nM | 6.06 | Inhibition of DNA decatenation activity of Staphylococcus aureus DNA topoisomera... | 20404126 |
| Unchecked | IC50 | = | 950.0 | nM | 6.02 | Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase | 20404126 |
| DNA gyrase subunit A | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S... | 20404126 |
| DNA gyrase | IC50 | = | 1600.0 | nM | 5.8 | Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyrase | 20404126 |
| DNA gyrase subunit A | IC50 | = | 1700.0 | nM | 5.77 | Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C... | 20404126 |
| DNA gyrase subunit A | IC50 | = | 3800.0 | nM | 5.42 | Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA S83W... | 20404126 |
| Unchecked | IC50 | = | 6000.0 | nM | 5.22 | Inhibition of DNA decatenation activity of Escherichia coli DNA topoisomerase 4 | 20404126 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20404126 | 10.1128/aac.00190-10 | Unchecked | 13 |
| 20404126 | 10.1128/aac.00190-10 | DNA gyrase subunit A | 6 |
| 20404126 | 10.1128/aac.00190-10 | DNA gyrase | 1 |
Data from ChEMBL 36 via Core Engine