Assay Detail
Functional
CHEMBL1283082
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Antileishmanial activity against intracellular Leishmania major amastigotes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel arylimidamides for treatment of visceral leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.26 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1275764 | — | — | 1 | 7.85 |
| CHEMBL1276549 | — | — | 1 | 7.58 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.68 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 4.60 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.60 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1275764 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1276549 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL370143 | PAROMOMYCIN | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL55 | PENTAMIDINE | IC50 | - | — | - |