Assay Detail
Functional
CHEMBL1283083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against intracellular Leishmania donovani LV82 amastigotes infected in CD-1 mouse peritoneal macrophage
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel arylimidamides for treatment of visceral leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.09 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1275764 | — | — | 1 | 5.55 |
| CHEMBL1276549 | — | — | 1 | 5.35 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 5.09 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.85 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.62 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1275764 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1276549 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL370143 | PAROMOMYCIN | IC50 | > | 100000.0 | nM | - |