Assay Detail
Binding
CHEMBL1284664
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Inhibition of DNA supercoiling activity of wild type Mycobacterium tuberculosis DNA gyrase A
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.97 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1256993 | — | — | 1 | 5.54 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 5.04 |
| CHEMBL31 | GATIFLOXACIN | 4.0 | 1 | 5.03 |
| CHEMBL5315124 | LEVOFLOXACIN | 4.0 | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1256993 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL31 | GATIFLOXACIN | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5315124 | LEVOFLOXACIN | IC50 | = | 52000.0 | nM | 4.28 |