Assay Detail
Binding
CHEMBL1285239
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Inhibition of jack bean urease assessed as ammonia production after 15 mins by indophenol method
29
Total Activities
19
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 18 | - | - |
| IC50 | 10 | 4.21 | 4.34 |
| IC10 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1277360 | — | — | 2 | 4.34 |
| CHEMBL1275864 | — | — | 2 | 4.07 |
| CHEMBL1277270 | — | — | 1 | - |
| CHEMBL1277359 | — | — | 1 | - |
| CHEMBL1277361 | — | — | 1 | - |
| CHEMBL1277450 | — | — | 2 | - |
| CHEMBL1277451 | — | — | 1 | - |
| CHEMBL1277452 | — | — | 2 | - |
| CHEMBL1277269 | — | — | 1 | - |
| CHEMBL1277547 | — | — | 1 | - |
| CHEMBL1277548 | — | — | 2 | - |
| CHEMBL1277638 | — | — | 2 | - |
| CHEMBL1277639 | — | — | 2 | - |
| CHEMBL1275865 | — | — | 2 | - |
| CHEMBL1277640 | — | — | 2 | - |
| CHEMBL1277733 | — | — | 1 | - |
| CHEMBL1277734 | — | — | 1 | - |
| CHEMBL260876 | THIOUREA | — | 1 | - |
| CHEMBL1277546 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1277360 | — | IC50 | = | 45600.0 | nM | 4.34 |
| CHEMBL1275864 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL1277270 | — | Inhibition | = | 48.3 | % | - |
| CHEMBL1277359 | — | Inhibition | = | 48.3 | % | - |
| CHEMBL1277360 | — | Inhibition | = | 97.0 | % | - |
| CHEMBL1275864 | — | Inhibition | = | 93.4 | % | - |
| CHEMBL1277361 | — | Inhibition | = | 7.5 | % | - |
| CHEMBL1277450 | — | Inhibition | = | 53.1 | % | - |
| CHEMBL1277451 | — | Inhibition | = | 43.4 | % | - |
| CHEMBL1277452 | — | Inhibition | = | 64.8 | % | - |
| CHEMBL1277546 | — | Inhibition | = | 88.6 | % | - |
| CHEMBL1277547 | — | Inhibition | = | 27.1 | % | - |
| CHEMBL1277548 | — | Inhibition | = | 82.8 | % | - |
| CHEMBL1277638 | — | Inhibition | = | 52.8 | % | - |
| CHEMBL1277639 | — | Inhibition | = | 73.4 | % | - |
| CHEMBL1277269 | — | Inhibition | = | 6.8 | % | - |
| CHEMBL1277640 | — | Inhibition | = | 91.1 | % | - |
| CHEMBL1277733 | — | Inhibition | = | 12.4 | % | - |
| CHEMBL1277734 | — | Inhibition | = | 7.2 | % | - |
| CHEMBL1277450 | — | IC50 | = | 459560.0 | nM | - |
| CHEMBL1277452 | — | IC50 | = | 357030.0 | nM | - |
| CHEMBL1277546 | — | IC50 | = | 170760.0 | nM | - |
| CHEMBL1277548 | — | IC50 | = | 313200.0 | nM | - |
| CHEMBL1277638 | — | IC50 | = | 483550.0 | nM | - |
| CHEMBL1277639 | — | IC50 | = | 398200.0 | nM | - |
| CHEMBL1275865 | — | IC50 | = | 426100.0 | nM | - |
| CHEMBL1277640 | — | IC50 | = | 214700.0 | nM | - |
| CHEMBL260876 | THIOUREA | IC10 | = | 21.0 | uM | - |
| CHEMBL1275865 | — | Inhibition | = | 56.8 | % | - |