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Assay Detail

CHEMBL1285353

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Functional
Antagonist activity at dopamine D2 receptor
ChEMBL ↗
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL217) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

QSAR prediction of D2 receptor antagonistic activity of 6-methoxy benzamides.
Fatemi MH, Dorostkar F.
Eur J Med Chem (2010) 45 : 4856 -4862
PubMed 20728966 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 7.89 9.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1276325 — — 1 9.54
CHEMBL1276585 — — 1 9.30
CHEMBL23464 — — 1 9.17
CHEMBL1276560 — — 1 9.04
CHEMBL1276326 — — 1 8.96
CHEMBL22242 REMOXIPRIDE 4.0 1 8.92
CHEMBL282925 — — 1 8.89
CHEMBL1276327 — — 1 8.89
CHEMBL1276494 — — 1 8.85
CHEMBL1276559 — — 1 8.82
CHEMBL1276712 — — 1 8.77
CHEMBL1276647 — — 1 8.75
CHEMBL1276561 — — 1 8.64
CHEMBL1276350 — — 1 8.57
CHEMBL1276529 — — 1 8.54
CHEMBL1276496 — — 1 8.52
CHEMBL1276615 — — 1 8.49
CHEMBL1276375 — — 1 8.38
CHEMBL1276763 — — 1 8.30
CHEMBL1276645 — — 1 8.28
CHEMBL1276616 — — 1 8.26
CHEMBL1276374 — — 1 8.25
CHEMBL1276740 — — 1 8.15
CHEMBL1276528 — — 1 8.11
CHEMBL1276738 — — 1 8.10
CHEMBL1276459 — — 1 8.08
CHEMBL1276400 — — 1 8.06
CHEMBL283099 — — 1 8.00
CHEMBL1276741 — — 1 7.96
CHEMBL1276739 — — 1 7.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1276325 — IC50 = 0.2884 nM 9.54
CHEMBL1276585 — IC50 = 0.5012 nM 9.30
CHEMBL23464 — IC50 = 0.6761 nM 9.17
CHEMBL1276560 — IC50 = 0.912 nM 9.04
CHEMBL1276326 — IC50 = 1.096 nM 8.96
CHEMBL22242 REMOXIPRIDE IC50 = 1.202 nM 8.92
CHEMBL282925 — IC50 = 1.288 nM 8.89
CHEMBL1276327 — IC50 = 1.288 nM 8.89
CHEMBL1276494 — IC50 = 1.413 nM 8.85
CHEMBL1276559 — IC50 = 1.514 nM 8.82
CHEMBL1276712 — IC50 = 1.698 nM 8.77
CHEMBL1276647 — IC50 = 1.778 nM 8.75
CHEMBL1276561 — IC50 = 2.291 nM 8.64
CHEMBL1276350 — IC50 = 2.692 nM 8.57
CHEMBL1276529 — IC50 = 2.884 nM 8.54
CHEMBL1276496 — IC50 = 3.02 nM 8.52
CHEMBL1276615 — IC50 = 3.236 nM 8.49
CHEMBL1276375 — IC50 = 4.169 nM 8.38
CHEMBL1276763 — IC50 = 5.012 nM 8.30
CHEMBL1276645 — IC50 = 5.248 nM 8.28
CHEMBL1276616 — IC50 = 5.495 nM 8.26
CHEMBL1276374 — IC50 = 5.623 nM 8.25
CHEMBL1276740 — IC50 = 7.079 nM 8.15
CHEMBL1276528 — IC50 = 7.762 nM 8.11
CHEMBL1276738 — IC50 = 7.943 nM 8.10
CHEMBL1276459 — IC50 = 8.318 nM 8.08
CHEMBL1276400 — IC50 = 8.71 nM 8.06
CHEMBL283099 — IC50 = 10.0 nM 8.00
CHEMBL1276741 — IC50 = 10.96 nM 7.96
CHEMBL1276739 — IC50 = 10.96 nM 7.96
CHEMBL1276711 — IC50 = 10.96 nM 7.96
CHEMBL1276428 — IC50 = 12.02 nM 7.92
CHEMBL1276460 — IC50 = 16.98 nM 7.77
CHEMBL1276646 — IC50 = 16.98 nM 7.77
CHEMBL1276742 — IC50 = 19.05 nM 7.72
CHEMBL1276352 — IC50 = 19.95 nM 7.70
CHEMBL1276461 — IC50 = 25.7 nM 7.59
CHEMBL1276527 — IC50 = 25.7 nM 7.59
CHEMBL1276708 — IC50 = 32.36 nM 7.49
CHEMBL1276426 — IC50 = 38.9 nM 7.41
CHEMBL1276677 — IC50 = 39.81 nM 7.40
CHEMBL1276268 — IC50 = 45.71 nM 7.34
CHEMBL282024 — IC50 = 52.48 nM 7.28
CHEMBL1276710 — IC50 = 56.23 nM 7.25
CHEMBL1276427 — IC50 = 57.54 nM 7.24
CHEMBL1276399 — IC50 = 64.57 nM 7.19
CHEMBL1276587 — IC50 = 67.61 nM 7.17
CHEMBL1276351 — IC50 = 67.61 nM 7.17
CHEMBL1276709 — IC50 = 70.79 nM 7.15
CHEMBL1276764 — IC50 = 109.65 nM 6.96