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Compound Detail

CHEMBL23464

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CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1OC

Basic Information

ChEMBL ID CHEMBL23464
Phase Preclinical
Structure Type MOL
InChI Key JJYGMNQCYKVCSO-NSHDSACASA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

418.3
MW (Da)
2.52
ALogP
4
HBA
1
HBD
50.8
PSA (Ų)
0.72
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H23IN2O3
MW 418.28
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.81

Activity Summary

IC50 2 meas. best 9.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL217
IC50 9.17 9.17 0.7 1
D(2) dopamine receptor
CHEMBL339
IC50 5.55 5.55 2790.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
4040977 10.1021/jm00147a025 Rattus norvegicus 2
4040977 10.1021/jm00147a025 D(2) dopamine receptor 1
20728966 10.1016/j.ejmech.2010.07.056 D(2) dopamine receptor 1

Data from ChEMBL 36 via Core Engine