Assay Detail
Binding
CHEMBL670668
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In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.80 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267723 | IOLOPRIDE | 2.0 | 1 | 8.47 |
| CHEMBL23403 | — | — | 1 | 8.33 |
| CHEMBL22472 | — | — | 1 | 8.32 |
| CHEMBL23437 | — | — | 1 | 8.20 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.92 |
| CHEMBL283099 | — | — | 2 | 7.92 |
| CHEMBL23228 | — | — | 1 | 7.72 |
| CHEMBL268555 | — | — | 1 | 7.58 |
| CHEMBL23845 | — | — | 1 | 7.41 |
| CHEMBL23519 | — | — | 1 | 7.25 |
| CHEMBL278767 | — | — | 1 | 7.19 |
| CHEMBL431490 | — | — | 1 | 6.91 |
| CHEMBL280953 | — | — | 1 | 6.82 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.63 |
| CHEMBL8945 | — | — | 1 | 6.50 |
| CHEMBL276977 | — | — | 1 | 6.44 |
| CHEMBL282925 | — | — | 1 | 6.04 |
| CHEMBL278560 | — | — | 1 | 6.01 |
| CHEMBL22242 | REMOXIPRIDE | 4.0 | 1 | 5.80 |
| CHEMBL23464 | — | — | 1 | 5.55 |
| CHEMBL279982 | — | — | 1 | 5.52 |
| CHEMBL23932 | — | — | 1 | 5.50 |
| CHEMBL282681 | — | — | 1 | 5.46 |
| CHEMBL282463 | — | — | 1 | 4.89 |
| CHEMBL282024 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267723 | IOLOPRIDE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL23403 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL22472 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL23437 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL283099 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL23228 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL283099 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL268555 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL23845 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL23519 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL278767 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL431490 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL280953 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL26 | SULPIRIDE | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL8945 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL276977 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL282925 | — | IC50 | = | 921.0 | nM | 6.04 |
| CHEMBL278560 | — | IC50 | = | 987.0 | nM | 6.01 |
| CHEMBL22242 | REMOXIPRIDE | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL23464 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL279982 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL23932 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL282681 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL282463 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL282024 | — | IC50 | = | 15300.0 | nM | 4.82 |